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The NIH Targeting RNA in Disease with Novel Technologies (TRDNT) Challenge

NIH RNA Funding Opportunity: Phase II Stage I Announced

The National Institutes of Health (NIH) has announced Phase II of the Targeting RNA in Disease with Novel Technologies (TRDNT) Challenge, a prize competition designed to accelerate the development of novel, precision RNA-targeting technologies for diseases that have long been untreatable.

Phase II offers up to $7.8 million in total prizes, with a focus on prototype development and use case demonstration. Unlike a grant, this is a prize challenge, so winners may use the funds at their discretion to further develop their technology.

Phase II: Stage I is open to U.S-based academic RNA researchers, early-stage innovators, research organizations, and biotech startups, among others. Phase I participation is not required.

Application Deadline

Applications open December 1st, 2026, and close February 1st, 2027.

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