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Optical Diagnostics

REDUCING PAIN, DISCOMFORT AND DEATHS BY DEVELOPING MINIMALLY INVASIVE TOOLS AND PROCEDURES EFFECTIVE AT DIAGNOSING DISEASES

Early diagnosis is critically important for effective therapy. Studies have conclusively shown that the earlier a disease is diagnosed, the greater the patient’s chance of recovery. Current diagnostic techniques for many diseases, however, are often invasive and inefficient. Certain types of cancer, like esophageal cancer, are diagnosed through repetitive random biopsies. Other diseases leave markers that are not feasible to access surgically, like the vulnerable plaque that can indicate heart disease.

CIMIT’s Optical Diagnostics Program seeks to make diagnosis efficient, effective, and non-invasive. Projects like Optical Coherence Tomography (OCT) and Optical Frequency Domain Imaging (OFDI) make it possible to identify precancerous lesions or arterial plaque at very early stages.

  • Projects
  • Publications
  • Forum/Events
  • In The News
  • Multimedia
FY 2011 - 2008 Optical Diagnostics Projects
YEAR PRINCIPAL INVESTIGATOR INSTITUTION PROJECT TITLE
2011 Balachundhar Subramaniam Beth Israel Deaconess Medical Center Echocardiography guided central oximetry-198
2010 Irving Bigio, PhD Boston University Validation of colon cancer screening by optical sensing of field effect in rectal mucosa
2010 Benjamin Vakoc, PhD Massachusetts
General Hospital
An image-guided laser therapy catheter for Barrett's esophagus
2010 Seok Yun, PhD Massachusetts
General Hospital
Dynamic cross sectional and functional imaging of vocal folds (4D laryngoscopy)
2009 Charles Lin, PhD Massachusetts
General Hospital
Label-free detection and quantification of circulating leukocytes by in vivo flow cytometry
2009 Dieter Manstein, MD Massachusetts
General Hospital
Non-invasive measurement of intraepidermal nerve density
2009 Seok Hyun Yun, PhD Massachusetts
General Hospital
Novel ocular biomechanical analysis
2008 Jerome Mertz, PhD Boston University Hybrid-Illumination Fluorescence Macroscopy with Out-of-Focus Blur Rejection
       
       
Recent Publications by CIMIT Investigators
INVESTIGATOR/AUTHOR PUBLICATION ARTICLE DATE
Akkin, T., Joo, C., de Boer, J. F. Biophys J.
15:93(4):1347-53
Depth-resolved Measurement
of Transient Structural Changes During Action Potential Propagation
2007
Boverman, G., Fang, Q.,
Carp., S. A., Miller, E. L.,
Brooks, D. H., Selb, J.
Moore, R. H., Kopans, D. B., Boas, D. A.
Phys Med Biol.
52(12):3618-41
Spatio-temporal Imaging fo the Hemoglobin in the Compressed Breast with Diffuse Optical
Tomography
2007
Chia, S., Christopher Raffel, O., Takano, M., Tearney, G. J., Bouma, B. E., Jang, I. K. Coron Artery Dis
18(6):423-7
In-vivo Comparison of Coronary Plaque Characteristics Using
Optical Coherence Tomography in Women vs. Men with Acute
Coronary Syndrome
2007
Desjardins, A. E., Vakoc, B. J., Tearney, G. J., Bouma, B. E. Opt Lett 32(21):3158-
60
Backscattering Spectroscopic Contrast with Angle-Resolved Optical Coherence Tomography 2007
Evans, J. A., Bouma, B. E., Bressner, J. Shishkov, M., Lauwers, G. Y., Mino-Kenudson,
M., Nikshioka, N. S., Tearney, G. J.
Gastrointest Endosc
65(1):50-6
Identifying Intestincal Metaplasia at the Squamocolumnar Junction
by Using Optical Coherence
Tomography
2007
Frangioni, J. V., Kim, S.
W., Ihnishi, S., Kim, S.,
Bawendi, M. G.
Methods Mol Biol
374:147”60
Sentinel Lymph Node Mapping
with Type-II Quantum Dots
2007
Joo. C., de Boer, J. F. Opt Lett. 32(16):2426-
8
Spectral-Domain Optical Coherence Reflectometric Sensor for Highly Sensitive Molecular Detection 2007
       
       
Optical Diagnostics at the
CIMIT Forum and Past Events
EVENT DATE SPEAKERS DETAIL
Lester Wolfe Workshop in Laser Biomedicine:
Shining Light on Melanoma
April 22, 2008

Arthur J. Sober, MD: MGH

Lihong Wang, PhD:
Washington Univ. in St. Louis

Zeina Tannous, MD: MGH

Mark F. Naylor, MD: University of Oklahoma

Framing the Problem of Melanoma Diagnosis

Photoacoustic Tomography and Melanoma Imaging


Clinical Imaging of Melanoma


Laser Immunotherapy for Melanoma

Forum: New Views of Inside the Body: Optical Imaging for Biomedical Applications Feb. 19, 2008

Gary Tearney, MD, MGH, CIMIT

Seok-Hyun (Andy) Yun, PhD, MGH

Seeing Inside: Optical Frequency Domain Imaging and
Ultra-Miniature Endoscopy

Endo-Microscopy and Biomechanical Engineering:
Novel Technologies and Applications

Lester Wolfe
Workshop: Laser
Biomedicine: Frontiers
in Modern
Microscopy
Nov. 20,
2007
Tony Wilson; Oxford University

Wonshik Choi; MIT

Carolyn Larabell; UC San Francisco,
Lawrence Berkeley National Lab

Xiaowei Zhuang; Harvard, Howard
Hughes Medical Institute

Johannes de Boer; MGH

Katrin Willig; Max Planck Institute for
Biophysical Chemistry

Katrin Kniepp; Harvard, MGH
•Making Light Work in
Microscopy

•Field-based Tomographic
Microscopy

•Imaging Cellular Structures
and Molecules with
X-ray Tomography

•Super-Resolution Optical
Microscopy with STORM

•3D Optical Coherence
Phase Microscopy

•STED Microscopy

•Nonlinear Microscopy in
Local Optical Fields
Forum: The Future
of Optical Medicine
May 29,
2007
Irving Bagio, PhD; BU
Sergio Fantini, PhD; Tufts

Guillermo Tearney, MD, PhD; MGH

David Benaron, MD; Stanford; CEO,
Spectros Corp.

Satish Singh, MD; BU
•The Future of Optical
Medicine
Lester Wolfe Workshop:
Experts on
Breast Cancer
Apr. 17,
2007
Barbara L. Smith; MD, PhD; MGH, HMS

Maryann Fitzmaurice, MD, PhD; Case
Western Reserve

Arjun Yodh, PhD; U. of Pennsylvania

Stephen Boppart, MD, PhD; U. of Illinois,
Mills Breast Cancer Institute
•Optical Methods in Breast
Cancer
       
Optical Diagnostics In the News
ARTICLE TITLE PUBLICATION DATE
New CIMIT grants fund optics and photonics innovations among high-potential medical research projects BioOptics Word May 19, 2009
Endoscopic imaging Channel 7 News Healthcast Jun. 24, 2008
     
Video: Channel 5 Chronicle - The Human Body Optical Diagnostics Segment
Dr. Tearney on Channel 5 Chronicle
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Gary Tearney, MD, PhDProgram Leader

Gary Tearney, MD, PhD
617-724-2979


CIMIT RESPONSIBILITIES
Program Leader,
Optical Diagnostics

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