The leading cause of death and disability in the developed world, Cardiovascular Disease affects millions of people of all ages and frequently requires painful and invasive treatments. Most advances in treating heart disease have focused on technological innovations to treat cardiovascular disease symptoms, rather than on improving methods of detection and diagnosis.
Heart disease costs the United States billions of dollars every year, yet much of the biology is still not understood. By continually evaluating the complex set of conditions cardiac patients experience, CIMIT investigators seek novel approaches to diagnosis and therapy.
CIMIT’s Cardiovascular Disease Program is working to develop novel methods for the identification of and therapy for patients at highest risk for developing myocardial infarction and stroke.
FY 2011 - 2008 Cardiovascular Disease Projects
|YEAR||PRINCIPAL INVESTIGATOR||INSTITUTION||PROJECT TITLE|
|2011||Antonis Armoundas, PhD||Massachusetts General Hospital||Advanced Pacing Methods for Preventing Life Threatening Arrhythmias|
|2011||Pedro del Nido||Children's Hospital Boston||Catheter-based adaptable device for closure of intracardiac defects in children|
|2010 - 2009||Robert A. Levine, MD||Massachusetts General Hospital||Operating on the Heart from Within - A Minimally Invasive Approach to Treat Mitral Valve Disease|
|2009||Judy Hung, MD, PhD||Massachusetts General Hospital||Polymer Injection for Treatment of Ischemic Mitral Regurgitation|
|2009||Guillermo Tearney MD, PhD||Massachusetts General Hospital||Integrated OFDI-Fluorescence Catheter for Imaging of Atherosclerosis|
|2008||Richard L. Verrier, MD
||Beth Israel Deaconess Medical Center||Develoment and Clinical Database Testing of Automated ECG Heterogeneity Analyzer for Real-Time Assessment of Risk for Lethal Arrhythmia|
Recent Publications by CIMIT Investigators
|Chia S, Christopher Raffel O, Takano M, Tearney GJ, Bouma BE, Jang IK.||Coron Artery Dis 18(6):423-7||In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome.||2007|
|Hung, J., Chaput, M., Guerrero, J. L., Handschumacher, M. D., Papakostas, L., Sullivan, S., Solis, J., Levine, R. A.||Circulation 11; 116(11 Suppl): I259-63||Persistent Reduction of Ischemic Mitral Regurgitation by Papillary Muscle Repositioning: Structural Stabilization of the Papillary Muscle-Ventricular Wall Complex||2007|
|Nadkarni SK, Pierce MC, Park BH, de Boer JF, Whittaker P, Bouma BE, Bressner JE, Halpern E, Houser SL, Tearney GJ||J Am Coll Cardiol. 49(13):1474-81, 2007.
Opt Lett. 32(11):1560-2, 2007.
|Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography.||2007|
|Raffel OC, Tearney GJ, Gauthier DD, Halpern EF, Bouma BE, Jang IK||Arterioscler Thromb Vasc Biol. (8):1820-7||Relationship between a systemic inflammatory marker, plaque inflammation, and plaque characteristics determined by intravascular optical coherence tomography.||2007|
|Soltesz, E. G., Laurence, R. G., De Grand, A. M., Cohn, L. H., Mihaljevic, T., Frangioni, J. V.
||Heart Surg Forum 10(5):E381-6||Image Guided Quantification of Cardioplegia Delivery During Cardiac Surgery||2007|
|Stone, P. H., Coskun, A. U., Kinlay, S., Popma, J. J., Sonka, M., Wahle, A., Yeghiazarians, Y., Maynard, C., Kuntz, R. E., Feldman, C. L.
||Eur Heart J 28(6): 705-10||Regions of Low Endothelial Shear Stress are the Sites Where Coronary Plaque Progresses and Vascular Remodeling Occurs in Humans: an In Vivo Serial Study||2007|
|Yelin R, Yelin D, Oh WY, Yun SH, Boudoux C, Vakoc BJ, Bouma BE, Tearney GJ.||J Biomed Opt. 12(6):064021||Multimodality optical imaging of embryonic heart microstructure.||2007|
Cardiovascular Disease at the
CIMIT Forum and Past Events
CIMIT Cardiovascular Conference 2008
|May 3-4, 2008||
This course will cover evolving concepts and novel methods for the identification of and therapy for patients at highest risk for developing myocardial infarction and stroke. Traditional diagnostic methods have proven invaluable for the management of atherosclerotic disease. Despite this, atherosclerotic diseases remain the leading killer of Americans. A major reason for this may lie in our limited ability to identify patients at highest risk for developing myocardial infarction and stroke. An enhanced understanding of methods and therapies to detect and treat such vulnerable patients will be offered through this course.
|Faculty: Thomas J. Brady, MD; CIMIT, MGH, HMS; Aloke Finn, MD; Emory; Pallav Garg MBBS, FRACP, MSc; BWH; Marie Denise Gerhard-Herman, MD; BWH; Udo Hoffmann, MD; HMS, MGH; Farouc Jaffer, MD, PhD; HMS, MGH; Peter Libby, MD; HMS, BWH; Mohammad Madjid, MD; Texas Heart Institute; James Muller, MD; Founder, CEO, President and Chief Medical Officer, InfraRedx; Christopher O’Donnell, MD, MPh; HMS, MGH; Jorge Plutzky, MD; HMS, BWH; Paul Ridker, MD; HMS, BWH; Ernst J. Schaefer, MD; Tufts University; Peter H. Stone, MD; HMS, BWH; Ahmed A. Tawakol, MD; CIMIT, MGH; Guillermo Tearney, MD, PhD; CIMIT, MGH; Geoff Vince, PhD; VP of Clinical and Scientific Affairs, Volcano Corporation; Renu Virmani, MD; President and Medical Director, CVPath, Institute, Inc.|
Cardiac Device Development
|Feb. 5, 2008||
Stephen N. Oesterle, MD: Senior Vice President, Medicine & Technology, Medtronic, Inc.
Donald S. Baim, MD: Executive Vice President, Chief Medical and Scientific Officer, Boston Scientific
|Forum: New Directions in Coronary Care
||Dec. 4, 2007||Ahmed Tawakol, MD; MGH
Sahil Parikh, MD; BWH
James Muller, MD; CEO, InfraReDx, Inc.
|Advances in Intracoronary Diagnostics and Therapeutics
• Drug Eluting Stents: Lessons in Biocompatibility
• Advances in Intracoronary Diagnostic Methods as a Means of Matching Type of Therapy with Type of Plaque
||Sep. 25, 2007||Antonis Armoundas, PhD; HMS, MIT, MGH
Richard L. Verrier, PhD, FACC, HMS, BIDMC, Harvard Institutes of Medicine
|• Repolarization Alternans: From the Patient to the Bench and Back to the Patient
• Dynamic Tracking of ECH Heterogeneity to Estimate Risk of Life-Threatening Arrythmias
|Forum: Cardiac Imaging and Electrode Placement Modeling
|Sep. 11, 2007
||Patrick O’Gara, MD; BWH
Matthew Jolley, MD; CHB
Jeroen Stinstra, PhD; SCI Institute Utah
|• Application of Cardiac Non-Invasive Imaging in Clinical Decision Making
• Modeling of Optimal ICD Electrode Placement in Children and Adults
|Forum: Mitral Valve Care
||Jun. 5, 2007||Judy Hung, MD; MGH, HMS
Michael Davidson, MD; BWH
|• Mechanism of Mitral Regurgitation: Insight from 3D Echo Toward Improving Repair
• From the Scalpel to the Catheter: Percutaneous Approaches to Mitral Valve Repair
|Made-for-the-military Products Put Brakes on Bleeding||CNN.com||March 2, 2007|
|More in Massachusetts Get Drug for Stroke||Boston Globe||October 20, 2006|
Video: CIMIT Life-Saving Innovation in Early Stage of Trauma.
Thomas Brady, MD