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Cardiovascular Disease


The leading cause of death and disability in the developed world, Cardiovascular Disease affects millions of people of all ages and frequently requires painful and invasive treatments. Most advances in treating heart disease have focused on technological innovations to treat cardiovascular disease symptoms, rather than on improving methods of detection and diagnosis.

Heart disease costs the United States billions of dollars every year, yet much of the biology is still not understood.  By continually evaluating the complex set of conditions cardiac patients experience, CIMIT investigators seek novel approaches to diagnosis and therapy.

CIMIT’s Cardiovascular Disease Program is working to develop novel methods for the identification of and therapy for patients at highest risk for developing myocardial infarction and stroke.

  • Projects
  • Publications
  • Forum/Events
FY 2011 - 2008 Cardiovascular Disease Projects
2011 Antonis Armoundas, PhD Massachusetts General Hospital Advanced Pacing Methods for Preventing Life Threatening Arrhythmias
2011 Pedro del Nido Children's Hospital Boston Catheter-based adaptable device for closure of intracardiac defects in children
2010 - 2009 Robert A. Levine, MD Massachusetts General Hospital Operating on the Heart from Within - A Minimally Invasive Approach to Treat Mitral Valve Disease
2009 Judy Hung, MD, PhD Massachusetts General Hospital Polymer Injection for Treatment of Ischemic Mitral Regurgitation
2009 Guillermo Tearney MD, PhD Massachusetts General Hospital Integrated OFDI-Fluorescence Catheter for Imaging of Atherosclerosis
2008 Richard L. Verrier, MD

Beth Israel Deaconess Medical Center Develoment and Clinical Database Testing of Automated ECG Heterogeneity Analyzer for Real-Time Assessment of Risk for Lethal Arrhythmia
Recent Publications by CIMIT Investigators
Chia S, Christopher Raffel O, Takano M, Tearney GJ, Bouma BE, Jang IK. Coron Artery Dis 18(6):423-7 In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome. 2007
Hung, J., Chaput, M., Guerrero, J. L., Handschumacher, M. D., Papakostas, L., Sullivan, S., Solis, J., Levine, R. A. Circulation 11; 116(11 Suppl): I259-63 Persistent Reduction of Ischemic Mitral Regurgitation by Papillary Muscle Repositioning: Structural Stabilization of the Papillary Muscle-Ventricular Wall Complex 2007
Nadkarni SK, Pierce MC, Park BH, de Boer JF, Whittaker P, Bouma BE, Bressner JE, Halpern E, Houser SL, Tearney GJ J Am Coll Cardiol. 49(13):1474-81, 2007.

Opt Lett. 32(11):1560-2, 2007.
Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography. 2007
Raffel OC, Tearney GJ, Gauthier DD, Halpern EF, Bouma BE, Jang IK Arterioscler Thromb Vasc Biol. (8):1820-7 Relationship between a systemic inflammatory marker, plaque inflammation, and plaque characteristics determined by intravascular optical coherence tomography. 2007
Soltesz, E. G., Laurence, R. G., De Grand, A. M., Cohn, L. H., Mihaljevic, T., Frangioni, J. V.
Heart Surg Forum 10(5):E381-6 Image Guided Quantification of Cardioplegia Delivery During Cardiac Surgery 2007
Stone, P. H., Coskun, A. U., Kinlay, S., Popma, J. J., Sonka, M., Wahle, A., Yeghiazarians, Y., Maynard, C., Kuntz, R. E., Feldman, C. L.

Eur Heart J 28(6): 705-10 Regions of Low Endothelial Shear Stress are the Sites Where Coronary Plaque Progresses and Vascular Remodeling Occurs in Humans: an In Vivo Serial Study 2007
Yelin R, Yelin D, Oh WY, Yun SH, Boudoux C, Vakoc BJ, Bouma BE, Tearney GJ. J Biomed Opt. 12(6):064021 Multimodality optical imaging of embryonic heart microstructure. 2007
Cardiovascular Disease at the
CIMIT Forum and Past Events

CIMIT Cardiovascular Conference 2008
HIGH-RISK PLAQUES: Detection and Management

May 3-4, 2008

This course will cover evolving concepts and novel methods for the identification of and therapy for patients at highest risk for developing myocardial infarction and stroke. Traditional diagnostic methods have proven invaluable for the management of atherosclerotic disease. Despite this, atherosclerotic diseases remain the leading killer of Americans. A major reason for this may lie in our limited ability to identify patients at highest risk for developing myocardial infarction and stroke. An enhanced understanding of methods and therapies to detect and treat such vulnerable patients will be offered through this course.

Faculty: Thomas J. Brady, MD; CIMIT, MGH, HMS; Aloke Finn, MD; Emory; Pallav Garg MBBS, FRACP, MSc; BWH; Marie Denise Gerhard-Herman, MD; BWH; Udo Hoffmann, MD; HMS, MGH; Farouc Jaffer, MD, PhD; HMS, MGH; Peter Libby, MD; HMS, BWH; Mohammad Madjid, MD; Texas Heart Institute; James Muller, MD; Founder, CEO, President and Chief Medical Officer, InfraRedx; Christopher O’Donnell, MD, MPh; HMS, MGH; Jorge Plutzky, MD; HMS, BWH; Paul Ridker, MD; HMS, BWH; Ernst J. Schaefer, MD; Tufts University; Peter H. Stone, MD; HMS, BWH; Ahmed A. Tawakol, MD; CIMIT, MGH; Guillermo Tearney, MD, PhD; CIMIT, MGH; Geoff Vince, PhD; VP of Clinical and Scientific Affairs, Volcano Corporation; Renu Virmani, MD; President and Medical Director, CVPath, Institute, Inc.
Cardiac Device Development


Feb. 5, 2008

Stephen N. Oesterle, MD: Senior Vice President, Medicine & Technology, Medtronic, Inc.

Donald S. Baim, MD: Executive Vice President, Chief Medical and Scientific Officer, Boston Scientific

Convergence in Health Care Technology: Devices, Biologics, Pharma, IT, Communications and Imaging

• Challenges in Cardiac Device Development

Forum: New Directions in Coronary Care

Dec. 4, 2007 Ahmed Tawakol, MD; MGH

Sahil Parikh, MD; BWH

James Muller, MD; CEO, InfraReDx, Inc.
Advances in Intracoronary Diagnostics and Therapeutics

• Drug Eluting Stents: Lessons in Biocompatibility

• Advances in Intracoronary Diagnostic Methods as a Means of Matching Type of Therapy with Type of Plaque

Sep. 25, 2007 Antonis Armoundas, PhD; HMS, MIT, MGH

Richard L. Verrier, PhD, FACC, HMS, BIDMC, Harvard Institutes of Medicine
• Repolarization Alternans: From the Patient to the Bench and Back to the Patient

• Dynamic Tracking of ECH Heterogeneity to Estimate Risk of Life-Threatening Arrythmias
Forum: Cardiac Imaging and Electrode Placement Modeling


Sep. 11, 2007
Patrick O’Gara, MD; BWH

Matthew Jolley, MD; CHB

Jeroen Stinstra, PhD; SCI Institute Utah
• Application of Cardiac Non-Invasive Imaging in Clinical Decision Making

• Modeling of Optimal ICD Electrode Placement in Children and Adults
Forum: Mitral Valve Care
Jun. 5, 2007 Judy Hung, MD; MGH, HMS

Michael Davidson, MD; BWH
• Mechanism of Mitral Regurgitation: Insight from 3D Echo Toward Improving Repair

• From the Scalpel to the Catheter: Percutaneous Approaches to Mitral Valve Repair
Program News
Made-for-the-military Products Put Brakes on Bleeding March 2, 2007
More in Massachusetts Get Drug for Stroke Boston Globe October 20, 2006
Video: CIMIT Life-Saving Innovation in Early Stage of Trauma.

Thomas Brady, MD Program Leaders

Thomas Brady, MD

Co-Program Leader,
Cardiovascular DIsease

Ahmed Tawakol, MDAhmed Tawakol, MD

Co-Program Leader,
Cardiovascular DIsease

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Boston Scientific


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